Making sure of survival

Making sure late endosomes are on time

Early endosomes collect and sort cargoes before maturing into late endosomes that ferry those cargoes to the lysosome. Liu et al. identify two proteins that spur early endosomes to transform and thus help ensure that cellular deliveries occur on schedule (1). As an early endosome morphs into a late endosome, it revamps its molecular composition. Early endosomes carry the GTPase Rab5, which attr...

Not a Sure Thing: Making Regulatory Choices

Commentary: Sure I'm Sure: Prefrontal Oscillations Support Metacognitive Monitoring of Decision Making

Accommodating the Needs of iConsumers: Making Sure They Get Their Money’s Worth of Digital Entertainment

The current methods of distributing music and film on the mass-market, either off-line or on-line, raise two types of consumer protection issues. First, consumers are not always in a position to know what they can and cannot do with their digital hardware and content. A lack of proper information and the ensuing failure of the products to meet the consumer’s expectations inevitably leads to dis...

Making sure that clinical trial results make a difference: operational research and the hierarchy of evidence.

Recent years have seen a growing interest in operational research as a means to support improvements in health care in lowand middle-income settings. In support of global efforts to expand access to antiretrovirals, for example, a substantial increase in operational research activities has helped to define models of care that work in resource-limited settings (Zachariah et al. 2012). Reflecting...